diff --git a/Octokit.Reactive/Clients/IObservableCommitCommentReactionsClient.cs b/Octokit.Reactive/Clients/IObservableCommitCommentReactionsClient.cs
index 2488a6fa..b44b78ba 100644
--- a/Octokit.Reactive/Clients/IObservableCommitCommentReactionsClient.cs
+++ b/Octokit.Reactive/Clients/IObservableCommitCommentReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 
 namespace Octokit.Reactive
 {
@@ -70,5 +71,26 @@ namespace Octokit.Reactive
         /// <param name="options">Options for changing the API response</param>
         /// <returns></returns>
         IObservable<Reaction> GetAll(long repositoryId, int number, ApiOptions options);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(string owner, string name, int commentId, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(long repositoryId, int commentId, int reactionId);
     }
 }
diff --git a/Octokit.Reactive/Clients/IObservableIssueCommentReactionsClient.cs b/Octokit.Reactive/Clients/IObservableIssueCommentReactionsClient.cs
index 6a8f032b..43fcef4e 100644
--- a/Octokit.Reactive/Clients/IObservableIssueCommentReactionsClient.cs
+++ b/Octokit.Reactive/Clients/IObservableIssueCommentReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 
 namespace Octokit.Reactive
 {
@@ -64,5 +65,26 @@ namespace Octokit.Reactive
         /// <param name="number">The comment id</param>
         /// <param name="options">Options for changing the API response</param>        
         IObservable<Reaction> GetAll(long repositoryId, int number, ApiOptions options);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(string owner, string name, int commentId, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-comment-reaction</remarks>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(long repositoryId, int commentId, int reactionId);
     }
 }
diff --git a/Octokit.Reactive/Clients/IObservableIssueReactionsClient.cs b/Octokit.Reactive/Clients/IObservableIssueReactionsClient.cs
index 8d762064..6acd9b27 100644
--- a/Octokit.Reactive/Clients/IObservableIssueReactionsClient.cs
+++ b/Octokit.Reactive/Clients/IObservableIssueReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 
 namespace Octokit.Reactive
 {
@@ -64,5 +65,26 @@ namespace Octokit.Reactive
         /// <param name="number">The issue id</param>
         /// <param name="reaction">The reaction to create </param>
         IObservable<Reaction> Create(long repositoryId, int number, NewReaction reaction);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="issueNumber">The issue number</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(string owner, string name, int issueNumber, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="issueNumber">The issue number</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(long repositoryId, int issueNumber, int reactionId);
     }
 }
diff --git a/Octokit.Reactive/Clients/IObservablePullRequestReviewCommentReactionsClient.cs b/Octokit.Reactive/Clients/IObservablePullRequestReviewCommentReactionsClient.cs
index ced771bd..0c3e06e0 100644
--- a/Octokit.Reactive/Clients/IObservablePullRequestReviewCommentReactionsClient.cs
+++ b/Octokit.Reactive/Clients/IObservablePullRequestReviewCommentReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 
 namespace Octokit.Reactive
 {
@@ -64,5 +65,26 @@ namespace Octokit.Reactive
         /// <param name="number">The comment id</param>
         /// <param name="reaction">The reaction to create</param>
         IObservable<Reaction> Create(long repositoryId, int number, NewReaction reaction);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(string owner, string name, int commentId, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        IObservable<Unit> Delete(long repositoryId, int commentId, int reactionId);
     }
 }
diff --git a/Octokit.Reactive/Clients/ObservableCommitCommentReactionsClient.cs b/Octokit.Reactive/Clients/ObservableCommitCommentReactionsClient.cs
index 8286a520..c95814ae 100644
--- a/Octokit.Reactive/Clients/ObservableCommitCommentReactionsClient.cs
+++ b/Octokit.Reactive/Clients/ObservableCommitCommentReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 using System.Reactive.Threading.Tasks;
 using Octokit.Reactive.Internal;
 
@@ -113,5 +114,38 @@ namespace Octokit.Reactive
 
             return _connection.GetAndFlattenAllPages<Reaction>(ApiUrls.CommitCommentReactions(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(string owner, string name, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(owner, name, commentId, reactionId).ToObservable();
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionid">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(long repositoryId, int commentId, int reactionid)
+        {
+            Ensure.ArgumentNotNull(reactionid, nameof(reactionid));
+
+            return _client.Delete(repositoryId, commentId, reactionid).ToObservable();
+        }
     }
 }
diff --git a/Octokit.Reactive/Clients/ObservableIssueCommentReactionsClient.cs b/Octokit.Reactive/Clients/ObservableIssueCommentReactionsClient.cs
index f6689482..9a4d61cd 100644
--- a/Octokit.Reactive/Clients/ObservableIssueCommentReactionsClient.cs
+++ b/Octokit.Reactive/Clients/ObservableIssueCommentReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 using System.Reactive.Threading.Tasks;
 using Octokit.Reactive.Internal;
 
@@ -110,5 +111,38 @@ namespace Octokit.Reactive
 
             return _connection.GetAndFlattenAllPages<Reaction>(ApiUrls.IssueCommentReactions(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(string owner, string name, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(owner, name, commentId, reactionId).ToObservable();
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-comment-reaction</remarks>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(long repositoryId, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(repositoryId, commentId, reactionId).ToObservable();
+        }
     }
 }
diff --git a/Octokit.Reactive/Clients/ObservableIssueReactionsClient.cs b/Octokit.Reactive/Clients/ObservableIssueReactionsClient.cs
index 19de83a0..12da4058 100644
--- a/Octokit.Reactive/Clients/ObservableIssueReactionsClient.cs
+++ b/Octokit.Reactive/Clients/ObservableIssueReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 using System.Reactive.Threading.Tasks;
 using Octokit.Reactive.Internal;
 
@@ -107,5 +108,38 @@ namespace Octokit.Reactive
 
             return _client.Create(repositoryId, number, reaction).ToObservable();
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="issueNumber">The issue number</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(string owner, string name, int issueNumber, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(owner, name, issueNumber, reactionId).ToObservable();
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="issueNumber">The issue number</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(long repositoryId, int issueNumber, int reactionId)
+        {
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(repositoryId, issueNumber, reactionId).ToObservable();
+        }
     }
 }
diff --git a/Octokit.Reactive/Clients/ObservablePullRequestReviewCommentReactionsClient.cs b/Octokit.Reactive/Clients/ObservablePullRequestReviewCommentReactionsClient.cs
index 1be8335d..967aaa1d 100644
--- a/Octokit.Reactive/Clients/ObservablePullRequestReviewCommentReactionsClient.cs
+++ b/Octokit.Reactive/Clients/ObservablePullRequestReviewCommentReactionsClient.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Reactive;
 using System.Reactive.Threading.Tasks;
 using Octokit.Reactive.Internal;
 
@@ -41,7 +42,7 @@ namespace Octokit.Reactive
             Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
             Ensure.ArgumentNotNull(options, nameof(options));
 
-            return _connection.GetAndFlattenAllPages<Reaction>(ApiUrls.PullRequestReviewCommentReaction(owner, name, number), null, AcceptHeaders.ReactionsPreview, options);
+            return _connection.GetAndFlattenAllPages<Reaction>(ApiUrls.PullRequestReviewCommentReactions(owner, name, number), null, AcceptHeaders.ReactionsPreview, options);
         }
 
         /// <summary>
@@ -66,7 +67,7 @@ namespace Octokit.Reactive
         {
             Ensure.ArgumentNotNull(options, nameof(options));
 
-            return _connection.GetAndFlattenAllPages<Reaction>(ApiUrls.PullRequestReviewCommentReaction(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
+            return _connection.GetAndFlattenAllPages<Reaction>(ApiUrls.PullRequestReviewCommentReactions(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
         }
 
         /// <summary>
@@ -99,5 +100,38 @@ namespace Octokit.Reactive
 
             return _client.Create(repositoryId, number, reaction).ToObservable();
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(string owner, string name, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(owner, name, commentId, reactionId).ToObservable();
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        public IObservable<Unit> Delete(long repositoryId, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNull(reactionId, nameof(reactionId));
+
+            return _client.Delete(repositoryId, commentId, reactionId).ToObservable();
+        }
     }
 }
diff --git a/Octokit.Tests.Integration/Clients/CommitCommentReactionsClientTests.cs b/Octokit.Tests.Integration/Clients/CommitCommentReactionsClientTests.cs
index 7e18eb69..237e9988 100644
--- a/Octokit.Tests.Integration/Clients/CommitCommentReactionsClientTests.cs
+++ b/Octokit.Tests.Integration/Clients/CommitCommentReactionsClientTests.cs
@@ -352,6 +352,54 @@ public class CommitCommentReactionsClientTests
             Assert.Equal(result.User.Id, reaction.User.Id);
         }
 
+
+        [IntegrationTest]
+        public async Task CanDeleteReaction()
+        {
+            var commit = await SetupCommitForRepository(_github);
+
+            var comment = new NewCommitComment("test");
+
+            var result = await _github.Repository.Comment.Create(_context.RepositoryOwner, _context.RepositoryName,
+                commit.Sha, comment);
+
+            foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+            {
+                var newReaction = new NewReaction(reactionType);
+
+                var reaction = await _github.Reaction.CommitComment.Create(_context.RepositoryOwner, _context.RepositoryName, result.Id, newReaction);
+
+                await _github.Reaction.CommitComment.Delete(_context.RepositoryOwner, _context.RepositoryName, result.Id, reaction.Id);
+            }
+
+            var finalComments = await _github.Reaction.CommitComment.GetAll(_context.RepositoryOwner, _context.RepositoryName, result.Id);
+
+            Assert.Empty(finalComments);
+        }
+
+        [IntegrationTest]
+        public async Task CanDeleteReactionWithRepositoryId()
+        {
+            var commit = await SetupCommitForRepository(_github);
+
+            var comment = new NewCommitComment("test");
+
+            var result = await _github.Repository.Comment.Create(_context.RepositoryId, commit.Sha, comment);
+
+            foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+            {
+                var newReaction = new NewReaction(reactionType);
+
+                var reaction = await _github.Reaction.CommitComment.Create(_context.RepositoryId, result.Id, newReaction);
+
+                await _github.Reaction.CommitComment.Delete(_context.RepositoryId, result.Id, reaction.Id);
+            }
+
+            var finalComments = await _github.Reaction.CommitComment.GetAll(_context.RepositoryId, result.Id);
+
+            Assert.Empty(finalComments);
+        }
+
         public void Dispose()
         {
             _context.Dispose();
diff --git a/Octokit.Tests.Integration/Clients/IssueCommentReactionsClientTests.cs b/Octokit.Tests.Integration/Clients/IssueCommentReactionsClientTests.cs
index 472218a0..50424130 100644
--- a/Octokit.Tests.Integration/Clients/IssueCommentReactionsClientTests.cs
+++ b/Octokit.Tests.Integration/Clients/IssueCommentReactionsClientTests.cs
@@ -322,6 +322,55 @@ public class IssueCommentReactionsClientTests
             Assert.Equal(issueComment.User.Id, issueCommentReaction.User.Id);
         }
 
+        [IntegrationTest]
+        public async Task CanDeleteReaction()
+        {
+            var newIssue = new NewIssue("a test issue") { Body = "A new unassigned issue" };
+            var issue = await _issuesClient.Create(_context.RepositoryOwner, _context.RepositoryName, newIssue);
+
+            Assert.NotNull(issue);
+
+            var issueComment = await _issuesClient.Comment.Create(_context.RepositoryOwner, _context.RepositoryName, issue.Number, "A test comment");
+
+            foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+            {
+                var newReaction = new NewReaction(reactionType);
+
+                var reaction = await _github.Reaction.IssueComment.Create(_context.RepositoryOwner, _context.RepositoryName, issueComment.Id, newReaction);
+
+                await _github.Reaction.IssueComment.Delete(_context.RepositoryOwner, _context.RepositoryName, issueComment.Id, reaction.Id);
+            }
+
+            var allReactions = await _github.Reaction.IssueComment.GetAll(_context.RepositoryOwner, _context.RepositoryName, issueComment.Id);
+
+            Assert.Empty(allReactions);
+        }
+
+        [IntegrationTest]
+        public async Task CanDeleteReactionWithRepositoryId()
+        {
+            var newIssue = new NewIssue("a test issue") { Body = "A new unassigned issue" };
+            var issue = await _issuesClient.Create(_context.RepositoryId, newIssue);
+
+            Assert.NotNull(issue);
+
+            var issueComment = await _issuesClient.Comment.Create(_context.RepositoryId, issue.Number, "A test comment");
+
+            Assert.NotNull(issueComment);
+
+            foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+            {
+                var newReaction = new NewReaction(reactionType);
+
+                var reaction = await _github.Reaction.IssueComment.Create(_context.RepositoryId, issueComment.Id, newReaction);
+                await _github.Reaction.IssueComment.Delete(_context.RepositoryId, issueComment.Id, reaction.Id);
+            }
+
+            var allReactions = await _github.Reaction.IssueComment.GetAll(_context.RepositoryId, issueComment.Id);
+
+            Assert.Empty(allReactions);
+        }
+
         public void Dispose()
         {
             _context.Dispose();
diff --git a/Octokit.Tests.Integration/Clients/IssueReactionsClientTests.cs b/Octokit.Tests.Integration/Clients/IssueReactionsClientTests.cs
index 9a396e87..b38bee71 100644
--- a/Octokit.Tests.Integration/Clients/IssueReactionsClientTests.cs
+++ b/Octokit.Tests.Integration/Clients/IssueReactionsClientTests.cs
@@ -286,6 +286,49 @@ public class IssueReactionsClientTests
             Assert.Equal(issue.User.Id, issueReaction.User.Id);
         }
 
+        [IntegrationTest]
+        public async Task CanDeleteReaction()
+        {
+            var newIssue = new NewIssue("a test issue") { Body = "A new unassigned issue" };
+            var issue = await _issuesClient.Create(_context.RepositoryOwner, _context.RepositoryName, newIssue);
+
+            Assert.NotNull(issue);
+
+            foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+            {
+                var newReaction = new NewReaction(reactionType);
+
+                var reaction = await _github.Reaction.Issue.Create(_context.RepositoryOwner, _context.RepositoryName, issue.Number, newReaction);
+                await _github.Reaction.Issue.Delete(_context.RepositoryOwner, _context.RepositoryName, issue.Number, reaction.Id);
+            }
+
+            var allReactions = await _github.Reaction.Issue.GetAll(_context.RepositoryOwner, _context.RepositoryName, issue.Number);
+
+            Assert.Empty(allReactions);
+        }
+
+        [IntegrationTest]
+        public async Task CanDeleteReactionWithRepositoryId()
+        {
+            var newIssue = new NewIssue("a test issue") { Body = "A new unassigned issue" };
+            var issue = await _issuesClient.Create(_context.RepositoryOwner, _context.RepositoryName, newIssue);
+
+            Assert.NotNull(issue);
+
+            foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+            {
+                var newReaction = new NewReaction(reactionType);
+
+                var reaction = await _github.Reaction.Issue.Create(_context.RepositoryOwner, _context.RepositoryName, issue.Number, newReaction);
+                await _github.Reaction.Issue.Delete(_context.RepositoryId, issue.Number, reaction.Id);
+            }
+
+            var allReactions = await _github.Reaction.Issue.GetAll(_context.RepositoryId, issue.Number);
+
+            Assert.Empty(allReactions);
+
+        }
+
         public void Dispose()
         {
             _context.Dispose();
diff --git a/Octokit.Tests.Integration/Clients/PullRequestReviewCommentReactionsClientTests.cs b/Octokit.Tests.Integration/Clients/PullRequestReviewCommentReactionsClientTests.cs
index 9558c1dd..3e051184 100644
--- a/Octokit.Tests.Integration/Clients/PullRequestReviewCommentReactionsClientTests.cs
+++ b/Octokit.Tests.Integration/Clients/PullRequestReviewCommentReactionsClientTests.cs
@@ -339,6 +339,60 @@ public class PullRequestReviewCommentReactionsClientTests : IDisposable
         Assert.Equal(commentFromGitHub.User.Id, pullRequestReviewCommentReaction.User.Id);
     }
 
+    [IntegrationTest]
+    public async Task CanDeleteReaction()
+    {
+        var pullRequest = await CreatePullRequest(_context);
+
+        const string body = "A review comment message";
+        const int position = 1;
+
+        var createdComment = await CreateComment(body, position, pullRequest.Sha, pullRequest.Number);
+
+        var commentFromGitHub = await _client.GetComment(Helper.UserName, _context.RepositoryName, createdComment.Id);
+
+        AssertComment(commentFromGitHub, body, position);
+
+        foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+        {
+            var newReaction = new NewReaction(reactionType);
+
+            var reaction = await _github.Reaction.PullRequestReviewComment.Create(_context.RepositoryOwner, _context.RepositoryName, commentFromGitHub.Id, newReaction);
+            await _github.Reaction.PullRequestReviewComment.Delete(_context.RepositoryOwner, _context.RepositoryName, commentFromGitHub.Id, reaction.Id);
+        }
+
+        var allReactions = await _github.Reaction.PullRequestReviewComment.GetAll(_context.RepositoryOwner, _context.RepositoryName, commentFromGitHub.Id);
+
+        Assert.Empty(allReactions);
+    }
+
+    [IntegrationTest]
+    public async Task CanDeleteReactionWithRepositoryId()
+    {
+        var pullRequest = await CreatePullRequest(_context);
+
+        const string body = "A review comment message";
+        const int position = 1;
+
+        var createdComment = await CreateComment(body, position, pullRequest.Sha, pullRequest.Number);
+
+        var commentFromGitHub = await _client.GetComment(_context.RepositoryId, createdComment.Id);
+
+        AssertComment(commentFromGitHub, body, position);
+
+        foreach (ReactionType reactionType in Enum.GetValues(typeof(ReactionType)))
+        {
+            var newReaction = new NewReaction(reactionType);
+
+            var reaction = await _github.Reaction.PullRequestReviewComment.Create(_context.RepositoryId, commentFromGitHub.Id, newReaction);
+            await _github.Reaction.PullRequestReviewComment.Delete(_context.RepositoryId, commentFromGitHub.Id, reaction.Id);
+        }
+
+        var allReactions = await _github.Reaction.PullRequestReviewComment.GetAll(_context.RepositoryId, commentFromGitHub.Id);
+
+        Assert.Empty(allReactions);
+    }
+
     /// <summary>
     /// Creates the base state for testing (creates a repo, a commit in master, a branch, a commit in the branch and a pull request)
     /// </summary>
@@ -349,7 +403,7 @@ public class PullRequestReviewCommentReactionsClientTests : IDisposable
 
         // Creating a commit in master
 
-        var createdCommitInMaster = await CreateCommit(repoName, "Hello World!", "README.md", "heads/master", "A master commit message");
+        var createdCommitInMaster = await CreateCommit(repoName, "Hello World!", "README.md", "heads/main", "A master commit message");
 
         // Creating a branch
 
@@ -362,7 +416,7 @@ public class PullRequestReviewCommentReactionsClientTests : IDisposable
 
         // Creating a pull request
 
-        var pullRequest = new NewPullRequest("Nice title for the pull request", branchName, "master");
+        var pullRequest = new NewPullRequest("Nice title for the pull request", branchName, "main");
         var createdPullRequest = await _github.PullRequest.Create(Helper.UserName, repoName, pullRequest);
 
         var data = new PullRequestData
diff --git a/Octokit/Clients/CommitCommentReactionsClient.cs b/Octokit/Clients/CommitCommentReactionsClient.cs
index 674f1c60..320c35cd 100644
--- a/Octokit/Clients/CommitCommentReactionsClient.cs
+++ b/Octokit/Clients/CommitCommentReactionsClient.cs
@@ -116,5 +116,37 @@ namespace Octokit
 
             return ApiConnection.GetAll<Reaction>(ApiUrls.CommitCommentReactions(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repos/{owner}/{repo}/comments/{comment_id}/reactions/{reaction_id}")]
+        public Task Delete(string owner, string name, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+
+            return ApiConnection.Delete(ApiUrls.CommitCommentReaction(owner, name, commentId, reactionId));
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repositories/{id}/comments/{comment_id}/reactions/{reaction_id}")]
+        public Task Delete(long repositoryId, int commentId, int reactionId)
+        {
+            return ApiConnection.Delete(ApiUrls.CommitCommentReaction(repositoryId, commentId, reactionId));
+        }
     }
 }
diff --git a/Octokit/Clients/ICommitCommentReactionsClient.cs b/Octokit/Clients/ICommitCommentReactionsClient.cs
index c64c25fa..f35bb620 100644
--- a/Octokit/Clients/ICommitCommentReactionsClient.cs
+++ b/Octokit/Clients/ICommitCommentReactionsClient.cs
@@ -71,5 +71,26 @@ namespace Octokit
         /// <param name="options">Options for changing the API response</param> 
         /// <returns></returns>
         Task<IReadOnlyList<Reaction>> GetAll(long repositoryId, int number, ApiOptions options);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(string owner, string name, int commentId, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(long repositoryId, int commentId, int reactionId);
     }
 }
diff --git a/Octokit/Clients/IIssueCommentReactionsClient.cs b/Octokit/Clients/IIssueCommentReactionsClient.cs
index 4fd60ba4..aafaa87e 100644
--- a/Octokit/Clients/IIssueCommentReactionsClient.cs
+++ b/Octokit/Clients/IIssueCommentReactionsClient.cs
@@ -65,5 +65,26 @@ namespace Octokit
         /// <param name="number">The comment id</param>
         /// <param name="options">Options for changing the API response</param>        
         Task<IReadOnlyList<Reaction>> GetAll(long repositoryId, int number, ApiOptions options);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(string owner, string name, int commentId, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Commit Comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-commit-comment-reaction</remarks>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(long repositoryId, int commentId, int reactionId);
     }
 }
diff --git a/Octokit/Clients/IIssueReactionsClient.cs b/Octokit/Clients/IIssueReactionsClient.cs
index 0de3feff..bcd3a002 100644
--- a/Octokit/Clients/IIssueReactionsClient.cs
+++ b/Octokit/Clients/IIssueReactionsClient.cs
@@ -65,5 +65,26 @@ namespace Octokit
         /// <param name="number">The issue id</param>
         /// <param name="reaction">The reaction to create</param>
         Task<Reaction> Create(long repositoryId, int number, NewReaction reaction);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="issueNumber">The issue number</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(string owner, string name, int issueNumber, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="issueNumber">The issue number</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(long repositoryId, int issueNumber, int reactionId);
     }
 }
diff --git a/Octokit/Clients/IPullRequestReviewCommentReactionsClient.cs b/Octokit/Clients/IPullRequestReviewCommentReactionsClient.cs
index 96a47395..128856fb 100644
--- a/Octokit/Clients/IPullRequestReviewCommentReactionsClient.cs
+++ b/Octokit/Clients/IPullRequestReviewCommentReactionsClient.cs
@@ -65,5 +65,26 @@ namespace Octokit
         /// <param name="number">The comment id</param>
         /// <param name="reaction">The reaction to create</param>
         Task<Reaction> Create(long repositoryId, int number, NewReaction reaction);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The issue id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(string owner, string name, int commentId, int reactionId);
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The issue id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        Task Delete(long repositoryId, int commentId, int reactionId);
     }
 }
diff --git a/Octokit/Clients/IssueCommentReactionsClient.cs b/Octokit/Clients/IssueCommentReactionsClient.cs
index f8293501..da889c8f 100644
--- a/Octokit/Clients/IssueCommentReactionsClient.cs
+++ b/Octokit/Clients/IssueCommentReactionsClient.cs
@@ -110,5 +110,37 @@ namespace Octokit
 
             return ApiConnection.GetAll<Reaction>(ApiUrls.IssueCommentReactions(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue Comment
+        /// </summary>
+        /// <remarks>https://developer.github.com/v3/reactions/#list-reactions-for-a-commit-comment</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The issue id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repos/{owner}/{repo}/issues/comments/{comment_id}/reactions/{reaction_id}")]
+        public Task Delete(string owner, string name, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+
+            return ApiConnection.Delete(ApiUrls.IssueCommentReaction(owner, name, commentId, reactionId));
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue Comment
+        /// </summary>
+        /// <remarks>https://developer.github.com/v3/reactions/#list-reactions-for-a-commit-comment</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The issue id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repositories/{id}/issues/comments/{comment_id}/reactions/{reaction_id}")]
+        public Task Delete(long repositoryId, int commentId, int reactionId)
+        {
+            return ApiConnection.Delete(ApiUrls.IssueCommentReaction(repositoryId, commentId, reactionId));
+        }
     }
 }
diff --git a/Octokit/Clients/IssueReactionsClient.cs b/Octokit/Clients/IssueReactionsClient.cs
index 53c970e0..c8d2a2ad 100644
--- a/Octokit/Clients/IssueReactionsClient.cs
+++ b/Octokit/Clients/IssueReactionsClient.cs
@@ -110,5 +110,37 @@ namespace Octokit
 
             return ApiConnection.Post<Reaction>(ApiUrls.IssueReactions(repositoryId, number), reaction, AcceptHeaders.ReactionsPreview);
         }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="issueNumber">The issue id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repos/{owner}/{repo}/issues/{issue_number}/reactions/{reaction_id}")]
+        public Task Delete(string owner, string name, int issueNumber, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+
+            return ApiConnection.Delete(ApiUrls.IssueReaction(owner, name, issueNumber, reactionId));
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Issue
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-an-issue-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="issueNumber">The issue id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repositories/{id}/issues/{issue_number}/reactions/{reaction_id}")]
+        public Task Delete(long repositoryId, int issueNumber, int reactionId)
+        {
+            return ApiConnection.Delete(ApiUrls.IssueReaction(repositoryId, issueNumber, reactionId));
+        }
     }
 }
diff --git a/Octokit/Clients/PullRequestReviewCommentReactionsClient.cs b/Octokit/Clients/PullRequestReviewCommentReactionsClient.cs
index 7acd3692..a76ef8c5 100644
--- a/Octokit/Clients/PullRequestReviewCommentReactionsClient.cs
+++ b/Octokit/Clients/PullRequestReviewCommentReactionsClient.cs
@@ -45,7 +45,7 @@ namespace Octokit
             Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
             Ensure.ArgumentNotNull(options, nameof(options));
 
-            return ApiConnection.GetAll<Reaction>(ApiUrls.PullRequestReviewCommentReaction(owner, name, number), null, AcceptHeaders.ReactionsPreview, options);
+            return ApiConnection.GetAll<Reaction>(ApiUrls.PullRequestReviewCommentReactions(owner, name, number), null, AcceptHeaders.ReactionsPreview, options);
         }
 
         /// <summary>
@@ -73,7 +73,7 @@ namespace Octokit
         {
             Ensure.ArgumentNotNull(options, nameof(options));
 
-            return ApiConnection.GetAll<Reaction>(ApiUrls.PullRequestReviewCommentReaction(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
+            return ApiConnection.GetAll<Reaction>(ApiUrls.PullRequestReviewCommentReactions(repositoryId, number), null, AcceptHeaders.ReactionsPreview, options);
         }
 
         /// <summary>
@@ -92,7 +92,7 @@ namespace Octokit
             Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
             Ensure.ArgumentNotNull(reaction, nameof(reaction));
 
-            return ApiConnection.Post<Reaction>(ApiUrls.PullRequestReviewCommentReaction(owner, name, number), reaction, AcceptHeaders.ReactionsPreview);
+            return ApiConnection.Post<Reaction>(ApiUrls.PullRequestReviewCommentReactions(owner, name, number), reaction, AcceptHeaders.ReactionsPreview);
         }
 
         /// <summary>
@@ -108,7 +108,39 @@ namespace Octokit
         {
             Ensure.ArgumentNotNull(reaction, nameof(reaction));
 
-            return ApiConnection.Post<Reaction>(ApiUrls.PullRequestReviewCommentReaction(repositoryId, number), reaction, AcceptHeaders.ReactionsPreview);
+            return ApiConnection.Post<Reaction>(ApiUrls.PullRequestReviewCommentReactions(repositoryId, number), reaction, AcceptHeaders.ReactionsPreview);
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repos/{owner}/{repo}/pulls/comments/{comment_id}/reactions/{reaction_id}")]
+        public Task Delete(string owner, string name, int commentId, int reactionId)
+        {
+            Ensure.ArgumentNotNullOrEmptyString(owner, nameof(owner));
+            Ensure.ArgumentNotNullOrEmptyString(name, nameof(name));
+
+            return ApiConnection.Delete(ApiUrls.PullRequestReviewCommentReaction(owner, name, commentId, reactionId));
+        }
+
+        /// <summary>
+        /// Deletes a reaction for a specified Pull Request comment
+        /// </summary>
+        /// <remarks>https://docs.github.com/en/rest/reactions#delete-a-pull-request-comment-reaction</remarks>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="commentId">The comment id</param>
+        /// <param name="reactionId">The reaction id</param>
+        /// <returns></returns>
+        [ManualRoute("DELETE", "/repositories/{id}/pulls/comments/{comment_id}/reactions/{reaction_id}")]
+        public Task Delete(long repositoryId, int commentId, int reactionId)
+        {
+            return ApiConnection.Delete(ApiUrls.PullRequestReviewCommentReaction(repositoryId, commentId, reactionId));
         }
     }
 }
diff --git a/Octokit/Clients/ReactionsClient.cs b/Octokit/Clients/ReactionsClient.cs
index 65747e5b..eabca26b 100644
--- a/Octokit/Clients/ReactionsClient.cs
+++ b/Octokit/Clients/ReactionsClient.cs
@@ -58,6 +58,7 @@ namespace Octokit
         /// <returns></returns>
         [Preview("squirrel-girl")]
         [ManualRoute("DELETE", "/reactions/{reaction_id}")]
+        [Obsolete("This route no longer works and is replaced with individual routes in each client")]
         public Task Delete(int number)
         {
             return ApiConnection.Delete(ApiUrls.Reactions(number), new object(), AcceptHeaders.ReactionsPreview);
diff --git a/Octokit/Helpers/ApiUrls.cs b/Octokit/Helpers/ApiUrls.cs
index 4d3a8332..df99a617 100644
--- a/Octokit/Helpers/ApiUrls.cs
+++ b/Octokit/Helpers/ApiUrls.cs
@@ -479,6 +479,29 @@ namespace Octokit
             return "repositories/{0}/issues/{1}/reactions".FormatUri(repositoryId, number);
         }
 
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reaction of a specified issue.
+        /// </summary>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="number">The issue number</param>
+        /// <returns></returns>
+        public static Uri IssueReaction(string owner, string name, int number, int reaction)
+        {
+            return "repos/{0}/{1}/issues/{2}/reactions/{3}".FormatUri(owner, name, number, reaction);
+        }
+
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reaction of a specified issue.
+        /// </summary>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="number">The issue number</param>
+        /// <returns></returns>
+        public static Uri IssueReaction(long repositoryId, int number, int reaction)
+        {
+            return "repositories/{0}/issues/{1}/reactions/{2}".FormatUri(repositoryId, number, reaction);
+        }
+
         /// <summary>
         /// Returns the <see cref="Uri"/> for the timeline of a specified issue.
         /// </summary>
@@ -560,6 +583,29 @@ namespace Octokit
             return "repositories/{0}/issues/comments/{1}/reactions".FormatUri(repositoryId, number);
         }
 
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reaction of a specified issue comment.
+        /// </summary>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="number">The comment number</param>
+        /// <returns></returns>
+        public static Uri IssueCommentReaction(string owner, string name, int number, int reaction)
+        {
+            return "repos/{0}/{1}/issues/comments/{2}/reactions/{3}".FormatUri(owner, name, number, reaction);
+        }
+
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reaction of a specified issue comment.
+        /// </summary>
+        /// <param name="repositoryId">The owner of the repository</param>
+        /// <param name="number">The comment number</param>
+        /// <returns></returns>
+        public static Uri IssueCommentReaction(long repositoryId, int number, int reaction)
+        {
+            return "repositories/{0}/issues/comments/{1}/reactions/{2}".FormatUri(repositoryId, number, reaction);
+        }
+
         /// <summary>
         /// Returns the <see cref="Uri"/> for the specified comment.
         /// </summary>
@@ -618,6 +664,31 @@ namespace Octokit
             return "repositories/{0}/comments/{1}/reactions".FormatUri(repositoryId, number);
         }
 
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reaction of a specified commit comment.
+        /// </summary>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="number">The comment number</param>
+        /// <param name="reaction">The reaction number</param>
+        /// <returns></returns>
+        public static Uri CommitCommentReaction(string owner, string name, int number, int reaction)
+        {
+            return "repos/{0}/{1}/comments/{2}/reactions/{3}".FormatUri(owner, name, number, reaction);
+        }
+
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reaction of a specified commit comment.
+        /// </summary>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="number">The comment number</param>
+        /// <param name="reaction">The reaction number</param>
+        /// <returns></returns>
+        public static Uri CommitCommentReaction(long repositoryId, int number, int reaction)
+        {
+            return "repositories/{0}/comments/{1}/reactions/{2}".FormatUri(repositoryId, number, reaction);
+        }
+
         /// <summary>
         /// Returns the <see cref="Uri"/> that returns all of the assignees to which issues may be assigned.
         /// </summary>
@@ -1604,6 +1675,30 @@ namespace Octokit
             return "repositories/{0}/pulls/{1}/reviews/{2}".FormatUri(repositoryId, number, reviewId);
         }
 
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reactions of a specified pull request review comment.
+        /// </summary>
+        /// <param name="owner">The owner of the repository</param>
+        /// <param name="name">The name of the repository</param>
+        /// <param name="number">The comment number</param>
+        /// <returns></returns>
+        public static Uri PullRequestReviewCommentReactions(string owner, string name, int number)
+        {
+            return "repos/{0}/{1}/pulls/comments/{2}/reactions".FormatUri(owner, name, number);
+        }
+
+        /// <summary>
+        /// Returns the <see cref="Uri"/> for the reactions of a specified pull request review comment.
+        /// </summary>
+        /// <param name="repositoryId">The Id of the repository</param>
+        /// <param name="number">The comment number</param>
+        /// <returns></returns>
+        public static Uri PullRequestReviewCommentReactions(long repositoryId, int number)
+        {
+            return "repositories/{0}/pulls/comments/{1}/reactions".FormatUri(repositoryId, number);
+        }
+
+
         /// <summary>
         /// Returns the <see cref="Uri"/> for the reaction of a specified pull request review comment.
         /// </summary>
@@ -1611,9 +1706,9 @@ namespace Octokit
         /// <param name="name">The name of the repository</param>
         /// <param name="number">The comment number</param>
         /// <returns></returns>
-        public static Uri PullRequestReviewCommentReaction(string owner, string name, int number)
+        public static Uri PullRequestReviewCommentReaction(string owner, string name, int number, int reaction)
         {
-            return "repos/{0}/{1}/pulls/comments/{2}/reactions".FormatUri(owner, name, number);
+            return "repos/{0}/{1}/pulls/comments/{2}/reactions/{3}".FormatUri(owner, name, number, reaction);
         }
 
         /// <summary>
@@ -1622,9 +1717,9 @@ namespace Octokit
         /// <param name="repositoryId">The Id of the repository</param>
         /// <param name="number">The comment number</param>
         /// <returns></returns>
-        public static Uri PullRequestReviewCommentReaction(long repositoryId, int number)
+        public static Uri PullRequestReviewCommentReaction(long repositoryId, int number, int reaction)
         {
-            return "repositories/{0}/pulls/comments/{1}/reactions".FormatUri(repositoryId, number);
+            return "repositories/{0}/pulls/comments/{1}/reactions/{2}".FormatUri(repositoryId, number, reaction);
         }
 
         /// <summary>